Comprehensive analysis of the expression patterns and function of the FTO–LINE1 axis in yak tissues and muscle satellite cells
This comprehensive mapping of the <i>FTO</i> and <i>LINE1</i> mRNA expression patterns establishes a direct interaction between the <i>FTO</i> protein and <i>LINE1</i> RNA in yak. The findings suggest that <i>FTO</i> overexpression promotes muscle satellite cells differentiation, whereas <i>LINE1</i> negatively regulates myotube fusion. The study provides fundamental insights into the role of the <i>FTO</i>-<i>LINE1</i> axis in determining the fate of muscle satellite cells in yak, laying a solid theoretical foundation for future investigations.
Authors
- Jincheng Zhong (ORCID: https://orcid.org/0000-0002-1734-5887)
- Zhijuan Wu (ORCID: https://orcid.org/0000-0001-5878-108X)
- Xiangfei Zhang (ORCID: https://orcid.org/0000-0002-2186-5930)
- Zhixin Chai (ORCID: https://orcid.org/0000-0002-8671-6178)
- Xiaolin Luo (ORCID: https://orcid.org/0000-0001-9007-9813)
- Huan Yang (ORCID: https://orcid.org/0000-0002-3106-490X)
- Hongwen Zhao (ORCID: https://orcid.org/0000-0002-6024-7430)
- Zongliang Ma
Institutions
- Sichuan Academy Of Social Sciences (CN)
- Southwest Minzu University (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2024-09-05
- DOI
- https://doi.org/10.3389/fvets.2024.1448587
- Citations
- 1
- Primary Topic
- T-cell and Retrovirus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- Southwest Minzu University