VGLUT2 may improve cognitive function in depressed rats by protecting prefrontal cortex neurons
After 28 days of CUMS combined with isolation rearing, rats exhibited impairments in mood, cognition, learning, and social abilities, with neuronal damage and decreased VGLUT2 protein levels in the prefrontal cortex. Following fluoxetine intervention, VGLUT2 protein expression increased, neuronal repair in the prefrontal cortex occurred, depressive-like behavior improved, and cognitive learning and social abilities were restored.
Authors
- Yongxue Hu (ORCID: https://orcid.org/0000-0003-1950-3540)
- Shan Qing (ORCID: https://orcid.org/0000-0002-7700-0143)
- Tianpei Ma (ORCID: https://orcid.org/0000-0002-4510-9697)
- Yiming Wang (ORCID: https://orcid.org/0009-0006-0578-0132)
- Peifan Li (ORCID: https://orcid.org/0000-0002-4311-7415)
- Longfei Liu (ORCID: https://orcid.org/0000-0003-0274-4057)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Behavioral Neuroscience
- Published
- 2024-09-05
- DOI
- https://doi.org/10.3389/fnbeh.2024.1453161
- Citations
- 6
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China