Inhibitory effects of NaF on mitochondrial energy generation in human platelets in vitro
At relatively low levels, NaF has the potential to attenuate platelet function probably primarily through the inhibition of mitochondrial energy generation. Cytotoxicity may be directly related to ROS production. These findings suggest that when used topically, for example, for caries prevention in the oral cavity, NaF could interfere with wound healing and tissue regeneration by endogenous and exogenously added platelets in the form of PRP.
Authors
- Taisuke Watanabe (ORCID: https://orcid.org/0000-0003-1281-7117)
- Yutaka Kitamura (ORCID: https://orcid.org/0000-0002-3270-7831)
- Hideo Kawabata
- Tetsuhiro Tsujino (ORCID: https://orcid.org/0000-0002-3802-8581)
- Tomoharu Mochizuki (ORCID: https://orcid.org/0000-0003-2565-0221)
- Takashi Ushiki (ORCID: https://orcid.org/0000-0001-5590-2480)
- Hajime Okudera
- Tomoyuki Kawase (ORCID: https://orcid.org/0000-0003-4160-396X)
- Takao Watanabe (ORCID: https://orcid.org/0000-0002-7929-1781)
- Tomoni Kasahara
- Koji Nishiyama
Institutions
- Tokyo Dental College (JP)
- Niigata University Medical and Dental Hospital (JP)
- Niigata University (JP)
Publication Details
- Journal
- Frontiers in Toxicology
- Published
- 2024-09-05
- DOI
- https://doi.org/10.3389/ftox.2024.1421184
- Citations
- 2
- Primary Topic
- Renal function and acid-base balance
- Type
- article
- Field-Weighted Citation Impact
- 0.68