PCAF acetylates AIB1 to form a transcriptional coactivator complex to promote glycolysis in endometrial cancer
Our findings provide new clues that perturbation of normal homeostatic levels of AIB1 is linked with endometrial cancer. These findings suggest that targeting AIB1-mediated regulation of aerobic glycolysis may offer a novel therapeutic approach for endometrial cancer with high AIB1 expression, opening new avenues for personalized diagnostics and treatment strategies in this disease.
Authors
- Di Wu (ORCID: https://orcid.org/0000-0003-2462-4232)
- Mingyang Wang (ORCID: https://orcid.org/0000-0001-7201-5090)
- Zhifeng Yan (ORCID: https://orcid.org/0000-0002-6930-3128)
- Mingxia Li (ORCID: https://orcid.org/0000-0002-6941-7344)
- Yuanguang Meng (ORCID: https://orcid.org/0000-0002-6643-1335)
Institutions
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- Chinese General Hospital College of Nursing and Liberal Arts (PH)
- First Affiliated Hospital of Chinese PLA General Hospital (CN)
- The 309th Hospital of Chinese People's Liberation Army (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-09-05
- DOI
- https://doi.org/10.3389/fonc.2024.1442965
- Citations
- 3
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.86