Different characteristics of the tumor immune microenvironment among subtypes of salivary gland cancer
The TIME of ACC was the so-called immune desert type, which may explain the mechanisms of the poor response to ICPi in previous clinical trials. On the other hand, MEC<sub>high</sub> was the immune-inflamed type, and this may support the rationale of ICPi for this pathological subtype.
Authors
- Masato Komatsu (ORCID: https://orcid.org/0000-0003-2007-0252)
- Shigehisa Kitano (ORCID: https://orcid.org/0000-0002-4041-8298)
- Kazuko Sakai (ORCID: https://orcid.org/0000-0003-1822-2720)
- Yoshinori Imamura (ORCID: https://orcid.org/0000-0002-5202-531X)
- Takayuki Nakayama (ORCID: https://orcid.org/0000-0003-2389-2542)
- Naomi Kiyota (ORCID: https://orcid.org/0000-0001-8021-6116)
- Taiji Koyama (ORCID: https://orcid.org/0000-0002-2893-605X)
- Yoshiaki Nagatani (ORCID: https://orcid.org/0009-0000-6153-6456)
- Ken‐ichi Nibu (ORCID: https://orcid.org/0000-0002-5461-4871)
- Tetsuya Nakatsura (ORCID: https://orcid.org/0000-0003-3918-2385)
- Manami Shimomura
- Masanori Teshima (ORCID: https://orcid.org/0000-0002-4409-0525)
- Yohei Funakoshi
- Daiki Ikarashi (ORCID: https://orcid.org/0000-0001-8088-2848)
- Hironobu Minami (ORCID: https://orcid.org/0000-0001-8630-9145)
- Tomoo Itoh (ORCID: https://orcid.org/0000-0003-1498-5018)
- Kazuto Nishio
Institutions
- Kobe University Hospital (JP)
- The Cancer Institute Hospital (JP)
- National Cancer Center Hospital East (JP)
- Japanese Foundation For Cancer Research (JP)
- Kobe University (JP)
- Kindai University (JP)
Publication Details
- Journal
- Asia-Pacific Journal of Clinical Oncology
- Published
- 2024-09-04
- DOI
- https://doi.org/10.1111/ajco.14108
- Citations
- 7
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.98
Funders
- Ministry of Education, Culture, Sports, Science and Technology