Difluoroboron Complexes as Versatile Precursors for Steroid Modification. Lumiestrone‐Based Steroid Derivatives: Synthesis and Structural Studies
A preparation method for steroid-based difluoroboron complexes has been developed using lumiestrone as a steroid example. Previously inaccessible lumiestrone-based difluoroboron complexes annulated at positions 16 and 17 of the D ring have been prepared. Such difluoroboron complexes may have large synthetic potential for heterofunctionalization of steroids at the D ring. An application of a borylation mixture Ac<sub>2</sub>O-BF<sub>3</sub>⋅OEt<sub>2</sub> significantly simplify the preparation of steroid "dimers" bearing two estrone moieties connected at positions 2 and 2' via a linker. Crystal structures of key representatives have been determined by X-ray diffraction.
Authors
- M. A. Prezent (ORCID: https://orcid.org/0000-0002-2229-3225)
- Mikhail Evgenievich Minyaev (ORCID: https://orcid.org/0000-0002-4089-3697)
- И. В. Заварзин (ORCID: https://orcid.org/0000-0002-8194-5756)
- Anna А. Sukhanova (ORCID: https://orcid.org/0009-0002-2470-8305)
Institutions
- National Research University Higher School of Economics (RU)
- N.D. Zelinsky Institute of Organic Chemistry (RU)
Publication Details
- Journal
- Chemistry - An Asian Journal
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1002/asia.202400595
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00