The Role of Claudins in the Pathogenesis of Dextran Sulfate Sodium-Induced Experimental Colitis: The Effects of Nobiletin
Altered expression of the claudin isoforms -1, -2, and -4 disrupts tight junctions, exposing the lamina propria to microflora, leading to electrolyte disturbance and the development of ulcerative colitis. Nobiletin with its anti-inflammatory properties may be useful in IBD.
Authors
- Asmaa Al-Failakawi
- Rao Ms (ORCID: https://orcid.org/0000-0002-8815-2089)
- Islam Ullah Khan (ORCID: https://orcid.org/0009-0008-3116-4637)
- Aishah Al‐Jarallah
Institutions
- Kuwait University (KW)
Publication Details
- Journal
- Biomolecules
- Published
- 2024-09-04
- DOI
- https://doi.org/10.3390/biom14091122
- Citations
- 6
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Kuwait University
- College of Graduate Studies, Kuwait University