Intra‐ and extracellular real‐time analysis of perfused fibroblasts using an <scp>NMR</scp> bioreactor: A pilot study
Discrimination of intra- and extracellular metabolic contributions helps understanding the underlying mechanisms of mitochondrial disorders, uncovers potential metabolic biomarkers, and unravels metabolic pathway-specific adaptations in response to metabolic perturbations.
Authors
- Peter Vermathen (ORCID: https://orcid.org/0000-0001-8649-1098)
- Jean‐Marc Nuoffer (ORCID: https://orcid.org/0000-0003-3650-6153)
- Déborah Mathis (ORCID: https://orcid.org/0000-0002-2326-7782)
- Christoph Meyer (ORCID: https://orcid.org/0009-0000-6010-300X)
- Christian Urzì (ORCID: https://orcid.org/0000-0002-3048-9877)
Institutions
- University of Bern (CH)
- University Hospital of Bern (CH)
- University Children’s Hospital Bern (CH)
Publication Details
- Journal
- Journal of Inherited Metabolic Disease
- Published
- 2024-09-04
- DOI
- https://doi.org/10.1002/jimd.12794
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Science Foundation
- Inselspital, Universitätsspital Bern
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung