Synthesis, Photophysical Properties and Cytotoxic Activities of Isoxazole‐Containing Difluoroboron Complexes
ABSTRACT A large series of previously unknown isoxazole containing difluoroboron β‐diketonate has been designed and synthesized from the available starting compounds. The photophysical properties of obtained compounds were studied, and the effects of the substituents in aromatic and isoxazole cycles of the BF 2 complexes on the fluorescence were investigated. The effect of solvatochromism were demonstrated. Cytotoxic activity against MCF‐7 (breast carcinoma), HCT‐116 (colon carcinoma), A549 (pulmonary carcinoma) and WI38 (fibroblasts from lung tissue) cell lines was tested and moderate toxicity in the concentration range of 10–100 μM was found for several compounds.
Authors
- Kirill S. Sadovnikov (ORCID: https://orcid.org/0009-0006-0420-9970)
- Dmitry A. Vasilenko
- Е. Р. Милаева (ORCID: https://orcid.org/0000-0002-5489-3866)
- Yulia A. Gracheva (ORCID: https://orcid.org/0000-0003-4201-3523)
- Yuri K. Grishin (ORCID: https://orcid.org/0000-0001-7709-5245)
- Elena B. Averina (ORCID: https://orcid.org/0000-0002-6107-2003)
- В. А. Тафеенко (ORCID: https://orcid.org/0000-0001-9369-052X)
- Nadezhda E. Astakhova
- Alexei A. Yakushev (ORCID: https://orcid.org/0000-0001-7807-9546)
- Artem S. Sazonov
Institutions
- Lomonosov Moscow State University (RU)
Publication Details
- Journal
- Journal of Heterocyclic Chemistry
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1002/jhet.4894
- Citations
- 1
- Primary Topic
- Luminescence and Fluorescent Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.12
Funders
- Russian Science Foundation