Prognostic value of nucleotide excision repair and translesion DNA synthesis proteins in muscle-infiltrating bladder carcinoma
Our study showed significant correlations between the tumor expression of XPG and POLI, as well as NER and TLS as the whole pathways, and inferior OS. Hence, they could constitute prognostic biomarkers and potentially promising therapeutic targets in MIBC. However, a prospective trial is required for further validation, thereby overcoming the limitations of this study.
Authors
- Jan Roška (ORCID: https://orcid.org/0000-0002-6016-4328)
- Peter J. Makovicky (ORCID: https://orcid.org/0000-0001-9307-9982)
- Karol Kajo (ORCID: https://orcid.org/0000-0002-8178-1093)
- Csaba Biró
- Andrea Holíčková
- Thomas A. Ward (ORCID: https://orcid.org/0000-0003-0937-4554)
- Jana Obertová
- Patrik Palacka (ORCID: https://orcid.org/0000-0003-4505-0952)
- Miroslav Chovanec
- Eveline Órásová
- Miroslava Vallová
- Jozef Mardiak
Institutions
- Sci-Tech Daresbury (GB)
- Cancer Research Institute of the Slovak Academy of Sciences (SK)
- Biomedical Research Center of the Slovak Academy of Sciences (SK)
- Vysoká Škola Zdravotníctva a Sociálnej Práce sv. Alžbety (SK)
- Comenius University Bratislava (SK)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1186/s12885-024-12865-8
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Univerzita Komenského v Bratislave
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
- European Regional Development Fund