Evaluation of the Therapeutic Role of Using the Oil Extract of the Leaves and Stems of the Astragalus Spinosus Plant on Wound Healing in Adult Female Albino Mice

Skin wounds are a major disaster in health care due to the more number of traumas and pathological conditions. Natural wound healing involves a well- organized operation, consist of a chain of proceedings like hemostasis, inflammation, proliferation, and extracellular matrix remodeling. Five groups of adult female albino mice were used, and the dorsal region was clipped to a length (1 cm) after hair removal by shaving. She was treated with an ointment extracted from the oil extract of the leaves and stems of the astragalus plant at a concentration of (5% - 10%) for 14 days. The groups were treated for 7 days and half of them were dissected, then the rest of the groups were dissected after 14 days with continued treatment twice daily. The most notable results were wound healing and the return of skin tissue to its normal state, especially in the groups treated with the highest concentration of tree leaf oil extract ointment. The results showed that the skin tissues underwent cellular repair, the cell layers appeared in their natural shape, the keratin threads appeared in the form of ribbons and did not peel, and the dermis also contained fibers. Colloids, sebaceous glands and hair follicles.