Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune microenvironment in pancreatic cancer by activating the cGAS/STING pathway
This research uncovers a novel role of macrophage ANXA1 in pancreatic cancer. ANXA1-mediated regulation of efferocytosis by tumor-associated macrophages promotes antitumor immune response via STING signaling, suggesting potential treatment strategies for pancreatic cancer.
Authors
- Yu Pan (ORCID: https://orcid.org/0000-0002-7417-4551)
- Shihan Zhang (ORCID: https://orcid.org/0000-0002-2377-5760)
- Linlin Chen (ORCID: https://orcid.org/0000-0002-7237-5915)
- Heguang Huang
- Zelin Hou
- Fengchun Lu
- Linjin Chen
- Jiajing Lin
- Haizong Fang
- Yuwei Wu
Institutions
- Fujian Medical University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1136/jitc-2024-009318
- Citations
- 20
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 4.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Fujian Provincial Health Technology Project