A second-generation recombinant BCG strain combines protection against murine tuberculosis with an enhanced safety profile in immunocompromised hosts
Bacille Calmette-Guérin (BCG) remains the only licensed vaccine against tuberculosis (TB). While BCG protects against TB in children, its protection against pulmonary TB in adults is suboptimal, and the development of a better TB vaccine is a global health priority. Previously, we reported two recombinant BCG strains effective against murine TB with low virulence and lung pathology in immunocompromised mice and guinea pigs. We have recently combined these two recombinant BCG strains into one novel vaccine candidate (BCGΔBCG1419c::ESAT6-PE25SS) and evaluated its immunogenicity, efficacy and safety profile in mice. This new vaccine candidate is non-inferior to BCG in protection against TB, presents reduced pro-inflammatory immune responses and displays an enhanced safety profile.
Authors
- Mario Alberto Flores‐Valdez (ORCID: https://orcid.org/0000-0002-4125-1370)
- Socorro Miranda‐Hernandez
- Mirna Burciaga-Flores (ORCID: https://orcid.org/0000-0002-9095-3563)
- Andreas Kupz (ORCID: https://orcid.org/0000-0002-9259-7873)
- Michel de Jesús Aceves-Sánchez (ORCID: https://orcid.org/0000-0003-3116-6153)
- Guangzu Zhao (ORCID: https://orcid.org/0000-0002-0541-3125)
- César Pedroza-Roldán (ORCID: https://orcid.org/0000-0003-1654-3651)
- Cristian Alfredo Segura-Cerda (ORCID: https://orcid.org/0000-0002-5243-6805)
- Julia Seifert (ORCID: https://orcid.org/0000-0003-3367-1196)
- Ana Maria Valencia‐Hernandez (ORCID: https://orcid.org/0000-0002-3907-5806)
- Abel Gutiérrez‐Ortega (ORCID: https://orcid.org/0000-0002-5772-3950)
- Lidia del Pozo-Ramos
Institutions
- Universidad de Guadalajara (MX)
- Australian Institute of Tropical Health and Medicine (AU)
- Secretaría de Salud de Jalisco (MX)
- Centro de Investigación y Proyectos en Ambiente y Desarrollo (MX)
- James Cook University (AU)
Publication Details
- Journal
- Vaccine
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1016/j.vaccine.2024.126291
- Citations
- 5
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.95
Funders
- University of Oxford
- National Health and Medical Research Council