Application of Nanobiosensor engineering in the diagnosis of neurodegenerative disorders

Neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are hard to diagnose and treat early. They are characterised by progressive loss of neuronal function and structure leading to crippling cognitive, motor and psychiatric impairments. In recent years, nanobiosensor engineering has emerged as a promising way to address the limitations of traditional diagnostic methods for neurodegenerative diseases. Nanobiosensors which combine nanotechnology and biosensing principles can detect disease specific biomarkers with high sensitivity and specificity to enable early and accurate diagnosis. One of the key advantages of nanobiosensors in diagnosing neurodegenerative diseases is their ability to detect and quantify specific proteins or molecules that are biomarkers for these conditions. For example, accumulation of amyloid beta peptides and hyperphosphorylation of tau protein are hallmarks of Alzheimer's disease. Nanobiosensors can be designed to selectively bind to these biomarkers providing rapid and non-invasive method for early disease detection. This enables more targeted and personalized treatment approaches. Furthermore, nanomaterials have shown potential in biosensing applications due to their unique physical, optical, and electrical properties. Their small size, large surface-to-volume ratio, and tunable properties enable them to interact with biological molecules in remarkable ways. One notable property is their ability to be functionalized with molecular beacons, reporter molecules, pacification layers, and targeting biomolecules, creating highly sensitive and specific biofunctional nanoprobes. This review aims to explore the promising role of nanobiosensor engineering in the early diagnosis and management of neurodegenerative disorders. • review of the application of nanobiosensor technology in the diagnosis of neurodegenerative disorders. • Discussion of the challenges in current diagnostic methods and the potential of nanobiosensors. • Examination of various types of nanobiosensors, including electrochemical, optical, and magnetic-based sensors. • Recent advancements in nanobiosensor development, highlighting their sensitivity, specificity, and versatility in neurodegenerative diagnosis. • Insights into future directions and opportunities for further research in leveraging nanobiosensor technology.