Optogenetic Functional Activation Is Detrimental During Acute Ischemic Stroke in Mice
Our data suggest that increased neuronal activity during acute focal arterial occlusions can be detrimental, presumably due to increased metabolic demand, and may have implications for the clinical management of hyperacute stroke patients.
Authors
- Tsubasa Takizawa (ORCID: https://orcid.org/0000-0003-2605-7200)
- Paul Fischer (ORCID: https://orcid.org/0000-0001-7673-8552)
- David Y. Chung (ORCID: https://orcid.org/0000-0002-7149-5851)
- Sava Sakadžić (ORCID: https://orcid.org/0000-0001-6318-1193)
- Cenk Ayata (ORCID: https://orcid.org/0000-0002-3644-6042)
- Kazutaka Sugimoto (ORCID: https://orcid.org/0000-0002-7666-2620)
- Mohammad A. Yaseen (ORCID: https://orcid.org/0000-0002-4154-152X)
- Tao Qin (ORCID: https://orcid.org/0009-0006-2511-8373)
Institutions
- Northeastern University (US)
- Yamaguchi University (JP)
- Keio University (JP)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Stroke
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1161/strokeaha.124.048032
- Citations
- 6
- Primary Topic
- Photoreceptor and optogenetics research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- American Heart Association
- American Stroke Association
- Andrew David Heitman Foundation
- Berlin Institute of Health
- National Institutes of Health
- Japan Society for the Promotion of Science