Fludrocortisone dose–response relationship in septic shock: a randomised phase II trial
Enteral fludrocortisone resulted in detectable plasma fludrocortisone concentrations in the majority of critically ill patients with septic shock, although they varied widely indicating differing absorption and bioavailability. Its addition to hydrocortisone was not associated with shorter time to shock resolution.
Authors
- Sana Shan (ORCID: https://orcid.org/0000-0001-5416-6055)
- James Walsham (ORCID: https://orcid.org/0000-0001-6852-4378)
- Joshua Dalton (ORCID: https://orcid.org/0000-0002-9365-7903)
- Gregory Medley (ORCID: https://orcid.org/0000-0002-7462-9536)
- Carolyn Koch
- Laurent Billot (ORCID: https://orcid.org/0000-0002-4975-9793)
- Rinaldo Bellomo (ORCID: https://orcid.org/0000-0002-1650-8939)
- Simon R. Finfer (ORCID: https://orcid.org/0000-0002-2785-5864)
- John Myburgh (ORCID: https://orcid.org/0000-0003-4088-7016)
- Jeremy Cohen (ORCID: https://orcid.org/0000-0002-1356-8506)
- Peter Krüger (ORCID: https://orcid.org/0000-0002-3216-2958)
- Morag J. Young (ORCID: https://orcid.org/0000-0003-0450-5375)
- Jason Meyer (ORCID: https://orcid.org/0000-0002-9344-1280)
- Dorrilyn Rajbhandari
- Sandra Peake (ORCID: https://orcid.org/0000-0001-6682-7973)
- Dhaval Ghelani (ORCID: https://orcid.org/0009-0009-7150-0583)
- James P. McCullough (ORCID: https://orcid.org/0000-0002-7292-2237)
- Michael S. Roberts (ORCID: https://orcid.org/0000-0003-3894-5301)
- Antje Blumenthal (ORCID: https://orcid.org/0000-0003-3673-7015)
- Naomi E. Hammond (ORCID: https://orcid.org/0000-0002-6559-7747)
- Louise M. Burrell (ORCID: https://orcid.org/0000-0003-1863-7539)
- Balasubramanian Venkatesh (ORCID: https://orcid.org/0000-0002-3234-5244)
- David M. Evans (ORCID: https://orcid.org/0000-0003-0663-4621)
- Lorraine Mackenzie (ORCID: https://orcid.org/0000-0002-6990-6324)
- Loki Bjorn Johnk (ORCID: https://orcid.org/0000-0001-8698-9697)
Institutions
- The University of Sydney (AU)
- Baker Heart and Diabetes Institute (AU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- University of South Australia (AU)
- Royal Brisbane and Women's Hospital (AU)
- Royal North Shore Hospital (AU)
- Gold Coast Hospital (AU)
- Wesley Hospital (AU)
- Austin Hospital (AU)
- Princess Alexandra Hospital (AU)
- Blacktown & Mount Druitt Hospital (AU)
- UNSW Sydney (AU)
- Australia and New Zealand School of Government (AU)
- Basil Hetzel Institute (AU)
- Queen Elizabeth Hospital (AU)
- The George Institute for Global Health (AU)
- St George Hospital (AU)
- Mater Adult Hospital (AU)
- Austin Health (AU)
- Imperial College London (GB)
- The University of Adelaide (AU)
- Western Sydney University (AU)
Publication Details
- Journal
- Intensive Care Medicine
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1007/s00134-024-07616-z
- Citations
- 16
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.19
Funders
- Intensive Care Foundation
- Metro South Health
- Baker Foundation
- University of New South Wales
- Medical Research Council
- National Health and Medical Research Council