Spatial Transcriptomic Approach to Understanding Coronary Atherosclerotic Plaque Stability
Our study illuminates distinct cell-specific and regional transcriptional alterations present in unstable plaques. Furthermore, we characterize spatially resolved, in situ evidence supporting cellular transdifferentiation and intraplaque plasticity as significant contributors to plaque instability in human coronary atherosclerosis. Our results provide a powerful resource for the identification of novel mediators of acute coronary syndrome, opening new avenues for preventative and therapeutic treatments.
Authors
- Maria Gabriela Gastanadui
- Rakesh P. Patel (ORCID: https://orcid.org/0000-0002-1526-4303)
- Gregory A. Payne (ORCID: https://orcid.org/0000-0002-8525-8603)
- Amit Gaggar (ORCID: https://orcid.org/0000-0003-1586-5632)
- Robert P. Richter (ORCID: https://orcid.org/0000-0002-3753-1994)
- Vivek Nanda (ORCID: https://orcid.org/0000-0003-1724-7168)
- Silvio Litovsky (ORCID: https://orcid.org/0000-0002-3174-2192)
- Camilla Margaroli (ORCID: https://orcid.org/0000-0003-3952-0778)
- Dezhi Wang (ORCID: https://orcid.org/0000-0002-6265-9607)
- Dongqi Xing (ORCID: https://orcid.org/0000-0003-2227-3571)
- J. Michael Wells (ORCID: https://orcid.org/0000-0001-9612-5454)
Institutions
- University of Alabama at Birmingham (US)
- Protein Express (United States) (US)
- Birmingham VA Medical Center (US)
- Comprehensive Cardiovascular (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1161/atvbaha.123.320330
- Citations
- 33
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 7.94
Funders
- American Heart Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- Comprehensive Cardiovascular Center