Ethnic Diversity and Distinctive Features of Familial Versus Multifactorial Chylomicronemia Syndrome: Insights From the UK FCS National Registry
The frequency of gene variant distribution varies based on the ethnic origin of patients with FCS. Patients with FCS are at a higher risk of pancreatic complications while the prevalence of atherosclerotic cardiovascular disease is lower in FCS compared with MCS. Carriers of heterozygous pathogenic variants have an intermediate phenotype between FCS and variant-negative MCS.
Authors
- Handrean Soran (ORCID: https://orcid.org/0000-0003-1714-5014)
- Natalie Forrester (ORCID: https://orcid.org/0000-0003-0033-7423)
- Paul Downie (ORCID: https://orcid.org/0000-0001-8467-1175)
- Yee Teoh
- Alan G. Jones (ORCID: https://orcid.org/0000-0002-3482-2518)
- Robert A. Hegele (ORCID: https://orcid.org/0000-0003-2861-5325)
- Michael Mansfield (ORCID: https://orcid.org/0000-0002-1044-3935)
- Maryam Ferdousi
- Bilal Bashir (ORCID: https://orcid.org/0000-0003-3733-8331)
- Hannah Delaney
- Charlotte Dawson (ORCID: https://orcid.org/0000-0002-9621-6468)
- See Kwok (ORCID: https://orcid.org/0000-0002-4114-716X)
- Anthony S. Wierzbicki (ORCID: https://orcid.org/0000-0003-2756-372X)
- D. Datta (ORCID: https://orcid.org/0000-0001-7856-7363)
- Paul Hamilton (ORCID: https://orcid.org/0000-0001-6437-9185)
- Paul N. Durrington (ORCID: https://orcid.org/0000-0001-9561-7887)
- Jian Wang (ORCID: https://orcid.org/0000-0002-6759-0522)
- Dawn O’Sullivan
- Fiona Jenkinson
Institutions
- Western University (CA)
- Queen's University Belfast (GB)
- Marine Scotland (GB)
- North Bristol NHS Trust (GB)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- University of Aberdeen (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Wrexham Maelor Hospital (GB)
- Heart of England NHS Foundation Trust (GB)
- Royal Victoria Infirmary (GB)
- Bristol Royal Infirmary (GB)
- University of Manchester (GB)
- Manchester University NHS Foundation Trust (GB)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- Robarts Clinical Trials (CA)
- St. Thomas Hospital (CA)
- University Hospital Llandough (GB)
- Salisbury NHS Foundation Trust (GB)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1161/atvbaha.124.320955
- Citations
- 15
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.03
Funders
- National Institute for Health and Care Research
- Manchester Biomedical Research Centre