BLOOD REDOX STATUS IN DIFFERENT HUMAN PATHOLOGIES

<p>The <i>in vivo</i> determination of oxidative stress always remains a great challenge. Our approach in Liège CHU consists of simultaneously measuring in blood samples four different kinds of biomarkers: enzymatic and non-enzymatic antioxidants, trace elements, markers of oxidative damage to lipids, and identification of sources leading to increased reactive oxygen species (ROS) production. All these biomarkers (n = 16) have been investigated in patients: 1) with Abdominal Aortic Aneurysm (AAA)<sup>1 </sup>or operated for Thoracic Abdominal Dissection (TAD)<sup>2</sup>, 2) suffering from Chronic Obstructive Pulmonary Disease (COPD)<sup>3</sup> or FacioScapuloHumeral Myopathy (FSHM)<sup>4</sup>, 3) with COVID-19<sup>5,6 </sup>and 4) with delirium<sup>7</sup>. When compared to our internal reference values, depletion in non-enzymatic antioxidants (vitamin C, β-carotene, vitamin C/vitamin E ratio, thiol proteins) and trace elements (zinc, selenium) was observed in the majority of these pathologies. By contrast, increased levels in glutathione peroxidase, copper/zinc ratio, lipid peroxides (ROOH), and myeloperoxidase are common in all these diseases.</p>