High proportion of PD-1 and CD39 positive CD8+ tissue resident T lymphocytes correlates with better clinical outcome in resected human oesophageal adenocarcinoma
Resected OAC are variably infiltrated by PD-1 and CD39 DP TILs, an abundance of which among lymphocytes is associated with improved survival. This DP population has an increased, but still modest, frequency of TIM3 and LAG3 positivity compared to DN, and is in keeping with a functionally competent TRM phenotype.
Authors
- Tim Underwood (ORCID: https://orcid.org/0000-0001-9455-2188)
- Gessa Sugiyarto (ORCID: https://orcid.org/0000-0002-2686-0127)
- Tim Elliott (ORCID: https://orcid.org/0000-0003-1097-0222)
- Edward James (ORCID: https://orcid.org/0000-0001-8638-7928)
- Samuel L. Hill (ORCID: https://orcid.org/0000-0002-9590-2116)
- Jack Harrington (ORCID: https://orcid.org/0000-0003-2926-1223)
Institutions
- Oxford BioMedica (United Kingdom) (GB)
- Cancer Research UK Oxford Centre (GB)
- University of Southampton (GB)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1007/s00262-024-03799-y
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- University Hospital Southampton NHS Foundation Trust
- Cancer Research UK
- Royal College of Surgeons of England
- University of Southampton