The short-term efficacy of neoadjuvant SOX versus SOX plus immune checkpoint inhibitor following laparoscopic gastrectomy for locally advanced gastric cancer: a multicenter retrospective cohort study in China
Neoadjuvant SOX plus ICIs brings better tumor regression and similar TRAEs compared with SOX alone for LAGC. SOX + ICIs-LG is safe and feasible to conduct with less EBL. Surgeons should focus on the perioperative management to control POCs for patients with PNI < 40 and more EBL.
Authors
- Bo Wei (ORCID: https://orcid.org/0000-0001-7386-2689)
- Jianxin Cui (ORCID: https://orcid.org/0000-0003-3100-1519)
- Ning Ning (ORCID: https://orcid.org/0009-0000-5707-1027)
- Yongpu Yang
- Linde Sun
- Liqiang Song
- Lin Chen (ORCID: https://orcid.org/0000-0001-6935-1552)
- Yan Shi (ORCID: https://orcid.org/0000-0002-6580-5120)
- Zhen Yuan (ORCID: https://orcid.org/0009-0005-6147-4634)
- Jiajun Du
- Yuyuan Lu
- Hao Cui (ORCID: https://orcid.org/0000-0003-1185-5322)
Institutions
- Army Medical University (CN)
- Peking University (CN)
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- Southwest Hospital (CN)
- Peking University International Hospital (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1007/s00262-024-03802-6
- Citations
- 7
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.93
Funders
- National Natural Science Foundation of China