Circulating apoE4 protein levels from dried blood spots predict cognitive function in a large population‐based survey setting
An assay to quantify apoE4 levels from dried blood spot samples was applied. The apoE4 protein was detected as specific binding at ≥30,000 pg/mL in 28.4% of samples. Having the apoE4 protein was associated with worse cognitive performance. Higher apoE4 protein levels in those who have it were associated with better cognition. Cardiovascular factors influenced levels of apoE4 protein.
Authors
- Hannah Marie Horton
- Karen Andersen‐Ranberg (ORCID: https://orcid.org/0000-0003-1970-7076)
- Kristin Skogstrand (ORCID: https://orcid.org/0000-0002-0026-3711)
- Nis Borbye‐Lorenzen (ORCID: https://orcid.org/0000-0003-3725-4533)
- Anna Rieckmann
- Solveig Holmgaard
- Luzia M. Weiss
- Martina Börsch‐Supan (ORCID: https://orcid.org/0000-0002-1826-4018)
- Vania Panes Lundmark (ORCID: https://orcid.org/0000-0002-6041-5537)
- Axel Börsch‐Supan (ORCID: https://orcid.org/0000-0003-0470-8850)
- Yacila I. Deza‐Araujo (ORCID: https://orcid.org/0000-0002-2624-077X)
- Aijing Sun
Institutions
- Statens Serum Institut (DK)
- University of Southern Denmark (DK)
- Universität der Bundeswehr München (DE)
- Max Planck Institute for Social Law and Social Policy (DE)
- Umeå University (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1002/alz.14224
- Citations
- 6
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 1.89
Funders
- European Commission
- Max-Planck-Gesellschaft
- National Institute on Aging