Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism
Tet2-mediated CH sensitizes mice to a hypertensive stimulus. Mechanistically, the expansion of hematopoietic Tet2-deficient cells promotes hypertension due to elevated renal immune cell infiltration and activation of the NLRP3 inflammasome, with consequences on sodium retention. These data indicate that carriers of TET2 CH could be at elevated risk for the development of hypertension and that immune modulators could be useful in treating hypertension in this patient population.
Authors
- Luca Rolauer
- Abigail G. Wolpe (ORCID: https://orcid.org/0000-0002-4169-3697)
- Yoshimitsu Yura (ORCID: https://orcid.org/0000-0003-2618-8569)
- Brant E. Isakson (ORCID: https://orcid.org/0000-0002-7692-6294)
- Emiri Miura‐Yura (ORCID: https://orcid.org/0000-0002-5477-5886)
- Miranda E. Good (ORCID: https://orcid.org/0000-0001-7775-1863)
- Eunbee Park (ORCID: https://orcid.org/0000-0001-5609-4622)
- Megan A. Evans (ORCID: https://orcid.org/0000-0002-7338-3060)
- Ariel H. Polizio (ORCID: https://orcid.org/0000-0001-5413-7238)
- Maria Grandoch (ORCID: https://orcid.org/0000-0002-4382-1947)
- Kenneth Walsh (ORCID: https://orcid.org/0000-0001-7580-2276)
- Heather Doviak (ORCID: https://orcid.org/0000-0002-0720-3164)
- Lucila Marino (ORCID: https://orcid.org/0000-0001-6552-0195)
- Jesse D. Cochran (ORCID: https://orcid.org/0000-0001-9705-5785)
- Kyung‐Duk Min (ORCID: https://orcid.org/0000-0002-1000-2187)
Institutions
- Tufts Medical Center (US)
- Düsseldorf University Hospital (DE)
- Intarcia Therapeutics (United States) (US)
- Cardiovascular Research Center (BR)
- University of Virginia Medical Center (US)
- Heinrich Heine University Düsseldorf (DE)
- University of Virginia (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1161/circresaha.124.324492
- Citations
- 23
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 5.38
Funders
- U.S. Department of Defense
- National Aeronautics and Space Administration
- National Institutes of Health
- National Cancer Institute