Clinical spectrum and possible pathogenesis of progressive outer retinal necrosis
Combination the neurotropic characteristics of alphaherpesviruses and the signs of PORN, we hypothesised that the reactivated PORN virus originated from the lateral geniculate nucleus, then propagated along the optic nerve and was released at the terminals, causing necrosis of the entire sensory retina rather than just affecting the outer segment.
Authors
- Robert T. Chang (ORCID: https://orcid.org/0000-0002-2950-7951)
- Xiaofeng Lin (ORCID: https://orcid.org/0000-0002-4596-2196)
- Lu Lin (ORCID: https://orcid.org/0000-0002-3261-6569)
- Lili Liu (ORCID: https://orcid.org/0000-0001-8608-6471)
- Xiaohu Ding (ORCID: https://orcid.org/0000-0002-3385-6572)
- Xiongze Zhang (ORCID: https://orcid.org/0000-0001-5530-4202)
- Yangfan Yang (ORCID: https://orcid.org/0000-0001-9021-9652)
Institutions
- Nanchang University (CN)
- Sun Yat-sen University (CN)
- Smith-Kettlewell Eye Research Institute (US)
- Stanford University (US)
Publication Details
- Journal
- British Journal of Ophthalmology
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1136/bjo-2023-325113
- Citations
- 1
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- National Natural Science Foundation of China
- High-level Hospital Construction Project of Guangdong Provincial People's Hospital