Macrophage-Expressed Coagulation Factor VII Promotes Adverse Cardiac Remodeling
Extravascular TF-FVIIa-PAR2 complex signaling drives inflammatory macrophage polarization in ischemic heart disease. Targeting this signaling complex for specific therapeutic macrophage reprogramming following MI attenuates cardiac fibrosis and improves cardiovascular function.
Authors
- Wolfram Ruf (ORCID: https://orcid.org/0000-0002-6064-2166)
- Kristin Grunz
- Stefanie Finger
- Tobias Bopp (ORCID: https://orcid.org/0000-0002-3232-8065)
- Gregory S. Harms (ORCID: https://orcid.org/0000-0001-7167-7738)
- Jens Posma (ORCID: https://orcid.org/0000-0003-3971-7095)
- Michael R. Molitor (ORCID: https://orcid.org/0000-0001-6075-4996)
- Qi Luo
- Venkata Garlapati (ORCID: https://orcid.org/0000-0002-5337-3551)
- M Aluia (ORCID: https://orcid.org/0009-0007-6801-8783)
- Philip Wenzel (ORCID: https://orcid.org/0000-0002-5397-2781)
- Than Son Nguyen
Institutions
- Scripps Research Institute (US)
- Scripps Health (US)
- Wilkes University (US)
- Johannes Gutenberg University Mainz (DE)
- Maastricht University (NL)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- German Center for Infection Research (DE)
- Institute of Immunology (HR)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1161/circresaha.123.324114
- Citations
- 14
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 5.63