EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake
Endothelial EPAS1 attenuates atherosclerosis at sites of disturbed flow by maintaining EC proliferation via fatty acid uptake and metabolism. This endothelial repair pathway is inhibited in obesity, suggesting a novel triglyceride-PHD2 modulation pathway suppressing EPAS1 expression. These findings have implications for therapeutic strategies addressing vascular dysfunction in obesity.
Authors
- Daniela Pirri
- Clint L. Miller (ORCID: https://orcid.org/0000-0003-4276-3607)
- Scott P. Allen (ORCID: https://orcid.org/0000-0003-4418-7375)
- Urs Zingg (ORCID: https://orcid.org/0000-0001-9751-4064)
- Akiko Mammoto (ORCID: https://orcid.org/0000-0003-3448-7331)
- Weiping Han (ORCID: https://orcid.org/0000-0002-5023-2104)
- Emily V. Chambers (ORCID: https://orcid.org/0000-0003-1252-8059)
- Mark Dunning (ORCID: https://orcid.org/0000-0002-8853-9435)
- Torsten Schenkel (ORCID: https://orcid.org/0000-0001-5560-1872)
- Suowen Xu (ORCID: https://orcid.org/0000-0002-5488-5217)
- Tadanori Mammoto (ORCID: https://orcid.org/0009-0002-0985-0856)
- Elena Osto (ORCID: https://orcid.org/0000-0001-8196-5696)
- Thomas Koestler
- Francesco Donati (ORCID: https://orcid.org/0000-0002-5212-1248)
- Graeme M. Birdsey
- Liam McAllan (ORCID: https://orcid.org/0000-0002-6215-4289)
- Jovana Serbanovic‐Canic (ORCID: https://orcid.org/0000-0002-8835-1491)
- Jane Bennett
- William R. Scott (ORCID: https://orcid.org/0000-0001-5467-114X)
- Guianfranco Mazzei (ORCID: https://orcid.org/0000-0003-3515-6606)
- Gemma Vilahur (ORCID: https://orcid.org/0000-0002-2828-8873)
- Francesco Botrè (ORCID: https://orcid.org/0000-0001-5296-8126)
- Maria Fragiadaki (ORCID: https://orcid.org/0000-0002-1587-5577)
- Sophie E. Irving (ORCID: https://orcid.org/0000-0003-0772-1946)
- Paul C. Evans (ORCID: https://orcid.org/0000-0001-7975-681X)
- Charis Pericleous (ORCID: https://orcid.org/0000-0001-8804-0493)
- Blanca Tardajos-Ayllon
- Siyu Tian (ORCID: https://orcid.org/0000-0002-5854-1243)
- Yasmin Rasool
- Lida Kabir
Institutions
- Agency for Science, Technology and Research (SG)
- University of Science and Technology of China (CN)
- Queen Mary University of London (GB)
- Medical University of Graz (AT)
- Medical College of Wisconsin (US)
- General Medical Council (GB)
- Hospital de Sant Pau (ES)
- Hefei Institutes of Physical Science (CN)
- Office of Public Health Genomics (US)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- University Hospital of Zurich (CH)
- Lung Institute (US)
- Institute of Molecular and Cell Biology (RU)
- Federazione Medico Sportiva Italiana (IT)
- Spital Limmattal (CH)
- Insigneo (GB)
- William Harvey Research Institute (GB)
- MRC London Institute of Medical Sciences (GB)
- Imperial College London (GB)
- University of Virginia (US)
- Sheffield Hallam University (GB)
- Medical Research Council (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1161/circresaha.123.324054
- Citations
- 13
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 3.83
Funders
- Medical Research Council