Oncolytic virotherapy augments self-maintaining natural killer cell line cytotoxicity against neuroblastoma
To the best of our knowledge, these investigations are the first to demonstrate the effects of an oncolytic virus combined with self-maintaining NK cells in neuroblastoma and the priming effect of neuroblastoma on NK cells. The current studies provide a deeper understanding of the relation between NK cells and neuroblastoma and these data suggest that oHSV increases NK cell cytotoxicity towards neuroblastoma.
Authors
- Hooper R. Markert (ORCID: https://orcid.org/0000-0001-9698-5614)
- Swatika Butey (ORCID: https://orcid.org/0000-0003-1334-7073)
- James M. Markert (ORCID: https://orcid.org/0000-0001-7457-7329)
- Jianmei W. Leavenworth (ORCID: https://orcid.org/0000-0002-4100-9883)
- Elizabeth Ann Beierle (ORCID: https://orcid.org/0000-0002-4613-0527)
- Jennifer C. Coleman (ORCID: https://orcid.org/0000-0002-0666-9747)
- Janet R. Julson (ORCID: https://orcid.org/0000-0001-8213-443X)
- Colin H. Quinn (ORCID: https://orcid.org/0000-0001-7853-3948)
- Nazia Nazam (ORCID: https://orcid.org/0000-0003-0517-6841)
- Jerry E. Stewart (ORCID: https://orcid.org/0000-0003-4108-5381)
Institutions
- Children's of Alabama (US)
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1007/s00262-024-03818-y
- Citations
- 3
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- Rally Foundation
- National Institutes of Health