Challenges in the Diagnosis and Treatment of Invasive Candidiasis in India

The incidence of IC in India is 4-5% among patients admitted to the ICU, ~2% among hospitalized neonates, and 5%-10% among children with malignancy undergoing transplant or chemotherapy. The common risk factors for IC include chronic kidney disease, total parenteral nutrition, administration of broad-spectrum antibiotics for more than 7 to 10 days, abdominal surgery, underlying respiratory illness, and acute kidney injury. The five most dominant Candida species found in Indian ICUs include C. tropicalis, C. albicans, C. parapsilosis, C. glabrata, and C. krusei. In children, C. tropicalis, C. parapsilosis, C. albicans, C. auris, C. glabrata, and C. krusie are more common.