A new diphenyl ether from the cultured lichen mycobiont of <i>Graphis</i> cf. <i>handelii</i>
Lichen is well-known for its various purposes. However, understanding the chemical composition and antimicrobial characteristics of <i>Graphis</i> cf. <i>handelii</i> remains insufficient. In this study, a new compound, graphinone A (<b>1</b>), together with three known compounds, handelone (<b>2</b>), 4-<i>O</i>-methylhiascic acid (<b>3</b>), and ethyl orsellinate (<b>4</b>) were isolated and structurally elucidated. Their chemical structures were established using comprehensive spectroscopic data (1D- and 2D-NMR and HRESIMS). Compounds <b>1</b>-<b>4</b> were tested for antimicrobial activity against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and evaluated for the alpha-glucosidase inhibition.
Authors
- Chanat Aonbangkhen (ORCID: https://orcid.org/0000-0002-7378-1341)
- Ngoc‐Hong Nguyen (ORCID: https://orcid.org/0009-0003-1281-5346)
- Thanh‐Hung Do (ORCID: https://orcid.org/0000-0002-6118-3774)
- Thuc‐Huy Duong (ORCID: https://orcid.org/0000-0001-9891-4326)
- Duc‐Dung Pham
- Chuong Hoang Nguyen (ORCID: https://orcid.org/0000-0002-2860-3159)
- Thi‐Minh‐Dinh Tran (ORCID: https://orcid.org/0009-0005-3976-0570)
- Jirapast Sichaem
- Thi‐Phi‐Giao Vo
- Thu-Hoang-Mai Nguyen
- Minh-Truong-Tho Ho
Institutions
- Thammasat University (TH)
- Vietnam National University Ho Chi Minh City (VN)
- Ton Duc Thang University (VN)
- Chulalongkorn University (TH)
- Lampang Rajabhat University (TH)
- Ho Chi Minh City University of Education (VN)
- HUTECH University
- Ho Chi Minh City University of Technology (VN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1080/14786419.2024.2398736
- Citations
- 3
- Primary Topic
- Lichen and fungal ecology
- Type
- article
- Field-Weighted Citation Impact
- 3.09