The Quinine Odyssey: A Barometer of the State of Organic Synthesis Over Centuries
The year 2024 marks the 80<sup>th</sup> anniversary of the landmark formal synthesis of (±)-quinine completed by Woodward and Doering. This article examines the evolution of approaches to access this storied Cinchona alkaloid natural product which represent a microcosm the progress that has been made in organic synthesis over the past ~170 years. Seminal contributions led by Pasteur, Rabe, Woodward, Uskoković, Stork, Jacobsen, Hayashi, Maulide and others are discussed.
Authors
- Alex C. Bissember (ORCID: https://orcid.org/0000-0001-5515-2878)
Institutions
- University of Tasmania (AU)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2024-09-04
- DOI
- https://doi.org/10.1002/chem.202403021
- Citations
- 3
- Primary Topic
- Chemical synthesis and alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.75