Cross‐Species Insights into Trophoblast Invasion During Placentation Governed by Immune‐Featured Trophoblast Cells
Proper development of the placenta, the transient support organ forms after embryo implantation, is essential for a successful pregnancy. However, the regulation of trophoblast invasion, which is most important during placentation, remains largely unknown. Here, rats, mice, and pigs are used as biomedical models, used scRNA-seq to comparatively elucidate the regulatory mechanism of placental trophoblast invasion, and verified it using a human preeclampsia disease model combined with scStereo-seq. A dual-featured type of immune-featured trophoblast (iTrophoblast) is unexpectedly discovered. Interestingly, iTrophoblast only exists in invasive placentas and regulates trophoblast invasion during placentation. In a normally developing placenta, iTrophoblast gradually transforms from an immature state into a functional mature state as it develops. Whereas in the developmentally abnormal preeclamptic placenta, disordered iTrophoblast transformation leads to the accumulation of immature iTrophoblasts, thereby disrupting trophoblast invasion and ultimately leading to the progression of preeclampsia.
Authors
- Ting Gu
- Jianyu Gan (ORCID: https://orcid.org/0009-0001-6419-8867)
- Shengchen Gu
- Yue Ding (ORCID: https://orcid.org/0000-0002-7525-1221)
- Wenjing Wang (ORCID: https://orcid.org/0000-0001-6025-9848)
- Zhenfang Wu (ORCID: https://orcid.org/0000-0001-7647-7153)
- Gengyuan Cai (ORCID: https://orcid.org/0000-0003-3773-4713)
- Xupeng Zang (ORCID: https://orcid.org/0000-0002-6676-6266)
- Linjun Hong (ORCID: https://orcid.org/0000-0002-6554-7918)
- Lei Jiang (ORCID: https://orcid.org/0000-0002-8676-8859)
- Fanming Meng (ORCID: https://orcid.org/0000-0002-4763-6714)
- Dan Zhang (ORCID: https://orcid.org/0000-0002-2253-4690)
- Zheng Xu (ORCID: https://orcid.org/0000-0002-5374-4121)
- Yongzhong Wang (ORCID: https://orcid.org/0000-0001-5657-0879)
- Zicong Li
- Junsong Shi (ORCID: https://orcid.org/0000-0002-4042-3919)
- Yijun Shang
- Sixiu Huang
Institutions
- South China Agricultural University (CN)
- Sun Yat-sen University (CN)
- Key Laboratory of Guangdong Province (CN)
- Guangdong Academy of Agricultural Sciences (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1002/advs.202407221
- Citations
- 9
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 5.24
Funders
- National Key Research and Development Program of China