Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease

Using TSPO-PET imaging of mice with depleted microglia and scRadiotracing in an amyloid model, we provide first evidence that a microglia connectome can be assessed in the mouse brain. Microglia synchronicity is closely associated with cognitive decline in AD and could serve as an independent personalized biomarker for disease progression.

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Publication Details

Journal
Molecular Neurodegeneration
Published
2024-09-05
DOI
https://doi.org/10.1186/s13024-024-00752-6
Citations
4
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.99

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article

Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease

Lars Paeger, Xianyuan Xiang, Arthur Liesz, Steffanie Heindl et al.
4 citations
Molecular Neurodegeneration
Neuroinflammation and Neurodegeneration Mechanisms
0.99
article

Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease

Lars Paeger, Xianyuan Xiang, Arthur Liesz, Steffanie Heindl, Maura Malpetti, Florian Eckenweber, Maximilian Grosch, Robert Perneczky, Ann‐Christin Wendeln, Marc Beyer, Stephan Wagner, Artem Zatcepin, Sophia Stoecklein, Michael Willem, Collins Osei-Sarpong, Boris‐Stephan Rauchmann, Johannes Levin, Peter Bartenstein, Jonas J. Neher, Nathalie L. Albert, Gloria Biechele, Matthias Brendel, Katharina Büerger, Rainer Rupprecht, Sabina Tahirović, Johannes Gnörich, Desirée Brösamle, Yuan Shi, Karin Wind-Mark, Carolin Meyer, Christian Haass, Axel Rominger, Günter U. Höglinger, Jochen Herms, Anika Finze, Leonie Beyer, Mikael Simons, Nicolai Franzmeier, Laura M. Bartos, Samira Parhizkar, Simon Lindner, Sibylle Ilse Ziegler, Markus J. Riemenschneider, Sebastian T. Kunte
article en
4 citations

Abstract

Using TSPO-PET imaging of mice with depleted microglia and scRadiotracing in an amyloid model, we provide first evidence that a microglia connectome can be assessed in the mouse brain. Microglia synchronicity is closely associated with cognitive decline in AD and could serve as an independent personalized biomarker for disease progression.

Molecular NeurodegenerationVol. 19(1)
University of Bern (CH), German Cancer Research Center (DE), Washington University in St. Louis (US), Heidelberg University (DE), University of Cambridge (GB), University Hospital of Bern (CH), German Center for Neurodegenerative Diseases (DE), Cambridge University Hospitals NHS Foundation Trust (GB), LMU Klinikum (DE), University Hospital Regensburg (DE), Medizinische Hochschule Hannover (DE), Munich Cluster for Systems Neurology (DE), Hertie Institute for Clinical Brain Research (DE), Shenzhen Institutes of Advanced Technology (CN), Imperial College London (GB), University of Regensburg (DE), Ludwig-Maximilians-Universität München (DE), University of Gothenburg (SE), University of Sheffield (GB)
Eberhard Karls Universität Tübingen, Medical Research Council
Good health and well-being
Openalex Percentile: Top 24%
Neuroinflammation and Neurodegeneration Mechanisms
0.99
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