Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease
Using TSPO-PET imaging of mice with depleted microglia and scRadiotracing in an amyloid model, we provide first evidence that a microglia connectome can be assessed in the mouse brain. Microglia synchronicity is closely associated with cognitive decline in AD and could serve as an independent personalized biomarker for disease progression.
Authors
- Lars Paeger (ORCID: https://orcid.org/0000-0001-8716-3483)
- Xianyuan Xiang (ORCID: https://orcid.org/0000-0002-8125-9027)
- Arthur Liesz (ORCID: https://orcid.org/0000-0002-9069-2594)
- Steffanie Heindl (ORCID: https://orcid.org/0000-0003-3576-2702)
- Maura Malpetti (ORCID: https://orcid.org/0000-0001-8923-9656)
- Florian Eckenweber
- Maximilian Grosch (ORCID: https://orcid.org/0000-0001-9317-2001)
- Robert Perneczky (ORCID: https://orcid.org/0000-0003-1981-7435)
- Ann‐Christin Wendeln (ORCID: https://orcid.org/0000-0003-4586-6281)
- Marc Beyer (ORCID: https://orcid.org/0000-0001-9704-148X)
- Stephan Wagner (ORCID: https://orcid.org/0000-0002-3184-2599)
- Artem Zatcepin (ORCID: https://orcid.org/0000-0002-0224-088X)
- Sophia Stoecklein (ORCID: https://orcid.org/0000-0003-0325-4674)
- Michael Willem (ORCID: https://orcid.org/0000-0001-8829-3802)
- Collins Osei-Sarpong (ORCID: https://orcid.org/0000-0002-1093-5147)
- Boris‐Stephan Rauchmann (ORCID: https://orcid.org/0000-0003-4547-6240)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Peter Bartenstein (ORCID: https://orcid.org/0009-0005-0734-4994)
- Jonas J. Neher (ORCID: https://orcid.org/0000-0003-1346-8924)
- Nathalie L. Albert (ORCID: https://orcid.org/0000-0003-0953-7624)
- Gloria Biechele (ORCID: https://orcid.org/0009-0008-5161-9571)
- Matthias Brendel (ORCID: https://orcid.org/0000-0002-9247-2843)
- Katharina Büerger (ORCID: https://orcid.org/0000-0002-5898-9953)
- Rainer Rupprecht (ORCID: https://orcid.org/0000-0003-2939-9062)
- Sabina Tahirović (ORCID: https://orcid.org/0000-0003-4403-9559)
- Johannes Gnörich (ORCID: https://orcid.org/0000-0003-1554-7765)
- Desirée Brösamle (ORCID: https://orcid.org/0000-0002-3443-1584)
- Yuan Shi (ORCID: https://orcid.org/0000-0001-6135-1830)
- Karin Wind-Mark (ORCID: https://orcid.org/0000-0002-5461-1873)
- Carolin Meyer (ORCID: https://orcid.org/0000-0002-1498-4827)
- Christian Haass (ORCID: https://orcid.org/0000-0002-4869-1627)
- Axel Rominger (ORCID: https://orcid.org/0000-0002-1954-736X)
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Jochen Herms (ORCID: https://orcid.org/0000-0002-6201-1042)
- Anika Finze (ORCID: https://orcid.org/0000-0002-3966-5814)
- Leonie Beyer (ORCID: https://orcid.org/0000-0002-7358-4495)
- Mikael Simons (ORCID: https://orcid.org/0000-0001-5329-192X)
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
- Laura M. Bartos (ORCID: https://orcid.org/0009-0007-6158-319X)
- Samira Parhizkar (ORCID: https://orcid.org/0000-0001-5807-190X)
- Simon Lindner (ORCID: https://orcid.org/0009-0007-4379-4436)
- Sibylle Ilse Ziegler (ORCID: https://orcid.org/0000-0002-5321-4817)
- Markus J. Riemenschneider (ORCID: https://orcid.org/0000-0002-3742-2982)
- Sebastian T. Kunte
Institutions
- University of Bern (CH)
- German Cancer Research Center (DE)
- Washington University in St. Louis (US)
- Heidelberg University (DE)
- University of Cambridge (GB)
- University Hospital of Bern (CH)
- German Center for Neurodegenerative Diseases (DE)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- LMU Klinikum (DE)
- University Hospital Regensburg (DE)
- Medizinische Hochschule Hannover (DE)
- Munich Cluster for Systems Neurology (DE)
- Hertie Institute for Clinical Brain Research (DE)
- Shenzhen Institutes of Advanced Technology (CN)
- Imperial College London (GB)
- University of Regensburg (DE)
- Ludwig-Maximilians-Universität München (DE)
- University of Gothenburg (SE)
- University of Sheffield (GB)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1186/s13024-024-00752-6
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.99
Funders
- Eberhard Karls Universität Tübingen
- Medical Research Council