Nanoarchitecture‐Integrated Hydrogel Boosts Angiogenesis–Osteogenesis–Neurogenesis Tripling for Infected Bone Fracture Healing
Infected fracture healing is a complicated process that includes intricate interactions at the cellular and molecular levels. In addition to angiogenesis and osteogenesis, the significance of neurogenesis in fracture healing has also been recognized in recent years. Here, a nanocomposite hydrogel containing pH-responsive zinc-gallium-humic acids (HAs) nanoparticles is developed. Through the timed release of Zn<sup>2+</sup>, Ga<sup>3+</sup>, and HAs, the hydrogel exhibits potent antibacterial effects and promotes angiogenesis, osteogenesis, and neurogenesis. The enhanced neurogenesis further promotes angiogenesis and osteogenesis, forming a mutually supportive angiogenesis-osteogenesis-neurogenesis cycle at the fracture site. The hydrogel achieves rapid infected fracture healing and improves tissue regeneration in mice. This study proposes a comprehensive treatment approach that combines antibacterial effects with the regulation of tissue regeneration to improve infected fracture healing.
Authors
- Weixian Hu (ORCID: https://orcid.org/0000-0002-3792-4819)
- Meijun Tan
- Pengzhen Bu
- Kangkang Zha (ORCID: https://orcid.org/0000-0003-0421-5466)
- Mohammad‐Ali Shahbazi (ORCID: https://orcid.org/0000-0002-4860-3017)
- Bobin Mi (ORCID: https://orcid.org/0000-0002-6994-4363)
- Ze Lin (ORCID: https://orcid.org/0000-0002-1136-7129)
- Yuan Xiong (ORCID: https://orcid.org/0000-0003-1090-9288)
- Yanzhi Zhao (ORCID: https://orcid.org/0000-0003-4712-2083)
- Guohui Liu (ORCID: https://orcid.org/0000-0002-2013-1396)
- Wenqian Zhang
- Feng Qian (ORCID: https://orcid.org/0000-0002-2312-5936)
- Shengming Zhang (ORCID: https://orcid.org/0009-0004-0603-3601)
- Yiqiang Hu (ORCID: https://orcid.org/0000-0001-7616-6224)
Institutions
- Union Hospital (HK)
- University Medical Center Groningen (NL)
- Chongqing University (CN)
- University of Groningen (NL)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1002/advs.202406439
- Citations
- 17
- Primary Topic
- Bone fractures and treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.57
Funders
- National Science Foundation
- National Natural Science Foundation of China
- National Key Research and Development Program of China