6‐Thioguanine nucleotide levels are associated with infliximab but not adalimumab levels in inflammatory bowel disease patients on combination therapy
6-TGN levels were weakly associated with infliximab but not adalimumab levels in combination therapy. 6-TGN levels in the lower end of the therapeutic range (230-260 pmol/8 × 10<sup>8</sup> RBC) may be adequate to maintain higher infliximab levels, particularly with escalated infliximab dosing.
Authors
- Hana Liou
- Ida Hilmi (ORCID: https://orcid.org/0000-0001-7091-0032)
- Peter De Cruz (ORCID: https://orcid.org/0000-0002-3399-7236)
- Raja Affendi Raja Ali (ORCID: https://orcid.org/0000-0003-4995-3868)
- Natalie Yu (ORCID: https://orcid.org/0000-0001-7283-7246)
- Sara Vogrin (ORCID: https://orcid.org/0000-0002-1597-9421)
- Ola Niewiadomski (ORCID: https://orcid.org/0000-0003-3476-0422)
- Daniel R. van Langenberg (ORCID: https://orcid.org/0000-0003-3662-6307)
- Daniel Tassone (ORCID: https://orcid.org/0000-0002-1882-8135)
- Mark Lust
- Emily K. Wright (ORCID: https://orcid.org/0000-0003-3896-7826)
- Shu‐Chen Wei (ORCID: https://orcid.org/0000-0002-5017-5840)
- Steven Phan (ORCID: https://orcid.org/0000-0002-2757-4296)
- Antony B. Friedman (ORCID: https://orcid.org/0000-0002-8106-1280)
- Tanya Lee (ORCID: https://orcid.org/0000-0003-4559-9603)
- Julien D. Schulberg (ORCID: https://orcid.org/0000-0002-0257-6535)
- Jason Tjahyadi
- Damien M. Wu (ORCID: https://orcid.org/0000-0002-7463-0684)
- Jason Zhang (ORCID: https://orcid.org/0000-0002-4160-1684)
- William Connell
- Krishneel Dutt
- Nik S. Ding (ORCID: https://orcid.org/0000-0002-6232-1948)
- Michael A. Kamm (ORCID: https://orcid.org/0000-0003-3319-7199)
- Chamara Basnayake (ORCID: https://orcid.org/0000-0001-6103-769X)
- Gregory Moore (ORCID: https://orcid.org/0000-0002-3689-8858)
- Luke Wang (ORCID: https://orcid.org/0000-0002-6818-0664)
- Alexander J. V. Thompson (ORCID: https://orcid.org/0000-0001-9882-0071)
Institutions
- University Malaya Medical Centre (MY)
- The University of Melbourne (AU)
- University Kebangsaan Malaysia Medical Centre (MY)
- University of Malaya (MY)
- St Vincent's Hospital Melbourne (AU)
- Eastern Health (AU)
- Monash Health (AU)
- National Taiwan University Hospital (TW)
- Alfred Health (AU)
- Austin Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Internal Medicine Journal
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1111/imj.16504
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.55