Effectiveness of intramuscular naloxone 1,600 μg in addition to titrated intravenous naloxone 100 μg for opioid poisoning: a randomised controlled trial
The addition of intramuscular naloxone 1,600 µg to titrated intravenous naloxone prolonged effective reversal of respiratory depression, with fewer naloxone doses and infusions given, and no significant difference in patients developing withdrawal.
Authors
- Geoffrey K. Isbister (ORCID: https://orcid.org/0000-0003-1519-7419)
- Elizabeth Currey (ORCID: https://orcid.org/0000-0002-2171-4999)
- Nicholas A. Buckley (ORCID: https://orcid.org/0000-0002-6326-4711)
- Katherine Isoardi (ORCID: https://orcid.org/0000-0002-1176-7923)
- Keith Harris (ORCID: https://orcid.org/0000-0003-0724-1088)
Institutions
- The University of Sydney (AU)
- The University of Queensland (AU)
- Princess Alexandra Hospital (AU)
- Princess Alexandra Hospital (GB)
- University of Newcastle Australia (AU)
Publication Details
- Journal
- Clinical Toxicology
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1080/15563650.2024.2396447
- Citations
- 4
- Primary Topic
- Opioid Use Disorder Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.17
Funders
- National Health and Medical Research Council