Enhancing Sensitivity in Nucleic Acid Detection via Collaborative Multiple Catalytic Cores in DNAzyme Nanomachines
We introduce a multicore DNA nanomachine (MDNM), utilizing four binary DNAzymes for nucleic acid detection without the need for a preamplification step. This innovation remarkably yields a reduction in limit of detection (LOD), over 5-fold, as compared to single-core systems. This reduces the required test time thus highlighting the potential of MDNM in advancing nucleic acid detection.
Authors
- Moustapha A. Y. Nour (ORCID: https://orcid.org/0000-0002-9264-8634)
- Andrey B. Komissarov (ORCID: https://orcid.org/0000-0003-1733-1255)
- Z. A. Hussein (ORCID: https://orcid.org/0009-0005-9763-5209)
- Dmitry M. Kolpashchikov (ORCID: https://orcid.org/0000-0002-8682-6553)
- Lidia A. Golovina
- Meera A. Alaji
- Ahmed Abdelkader ELdeeb
Institutions
- University of Central Florida (US)
- ITMO University (RU)
- Research Institute of Influenza (RU)
Publication Details
- Journal
- ChemBioChem
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1002/cbic.202400572
- Citations
- 1
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- ITMO University