33 Revised SDI

A key lupus outcome measure is the assessment of damage, which is considered as a separate domain to disease activity and health related quality of life and has been shown to independently predict mortality. 1 It is also known that damage begets damage and therefore prevention of damage is a key goal of novel systemic lupus erythematosus (SLE) therapies.Currently, the key damage assessment tool is the Systemic Lupus International Collaborating Clinics, ACR/ American College of Rheumatology (SLICC/ACR) Damage Index (SDI).This was developed 30 years ago and is widely used in lupus cohort studies. 1 Over time, several limitations of the SDI have been noted.It has a significant floor effect and, in any cohort, up to 50% of patients have no damage scored.The current SDI also only defines items using clinical examination and the results of simple investigations.Such definitions do not align with modern medical practice.Finally, any damage occurring prior to the diagnosis of lupus, for example in a patient with mixed connective tissue disease and pulmonary fibrosis who later that evolves into lupus, the pulmonary fibrosis is not counted in the damage index.For these and other reasons, damage takes a long time to accumulate and so is not used as a primary endpoint in SLE trials.Recently, the SLICC group, in collaboration with the ACR and the Lupus Foundation of America, have initiated a project to revise the SDI.By consensus we have agreed a new definition of the construct of damage; 'the SDI is a measure of morbidity in SLE, independent of disease activity or impact on the patient but related to mortality.It is an evaluative index primarily intended for research purposes and should take a life-course approach.Damage can occur before a diagnosis of SLE but, if so, it should be attributable to SLE.Damage to an organ is irreversible, but the functional consequences on that organ may improve over time through physiological adaptation or treatment'. 2 We have subsequently entered an item generation and item reduction phase, which included three rounds of a Delphi process as well as scrutiny by expert organ specific subgroups and an overall steering group. 3 After the most recent round we have identified 45 proposed items to be included.Of note, 11 of these items have staging within their proposed definitions suggesting that such an index may have more sensitivity.It also opens the possibility to consider reduction as well as increase in scores over time. 3 The revised SDI will likely offer a more detailed and clinically relevant assessment of organ damage in SLE patients.It will reflect current evidence based medical practice and is likely to improve sensitivity of the index in SLE populations.Further validation in cohorts and consideration of weighting of grades across clinical organ systems are now underway.