Effect of SGLT2 Inhibitors on Fibroblast Activation
Objective: To establish an in-vitro model and evaluate the cardioprotective potential for sodium-linked-glucose transporter 2 inhibitors (SGLT2i) in fibroblasts. We hypothesize that fibroblasts exposed to glucose experience oxidative stress and are sensitized to pathological stimuli such as TGFβ due to depletion of a protective antioxidant pathway.
Authors
- Nicole Henry
- Lauren St. John
- Buğra Özer (ORCID: https://orcid.org/0000-0002-1441-4162)
- Janet K. Lighthouse (ORCID: https://orcid.org/0000-0001-9838-6113)
- Eden Kiflom-Halldow
- A. Bill
Institutions
- St. John Fisher University (US)
Publication Details
- Journal
- American Journal of Pharmaceutical Education
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.ajpe.2024.100778
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00