Enhancing Neurosteroidogenesis Attenuates HIV-1 Tat Mediated Stress-Related Outcomes
Objective: To investigate the potential role of the neurotoxic HIV-1 regulatory protein, trans-activator of transcription (Tat), in hypothalamic-pituitary-adrenal (HPA) axis dysfunction and associated affective disorders, and to explore the hypothesis that enhancing neurosteroidogenesis could ameliorate Tat-mediated HPA dysfunction.
Authors
- Salahuddin Mohammed (ORCID: https://orcid.org/0000-0001-7306-5989)
- Fakhri Mahdi (ORCID: https://orcid.org/0000-0003-4891-2992)
- Jason J. Paris
Institutions
- Notre Dame of Maryland University (US)
- University of Mississippi (US)
Publication Details
- Journal
- American Journal of Pharmaceutical Education
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.ajpe.2024.100823
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 0.00