Defunctionalization Enabled by Intramolecular Radical Aromatic <i>Ipso</i> Substitution
A chemoselective and regioselective copper-promoted defunctionalization procedure has been developed, enabling the rapid construction of various <i>N</i>-polyheterocycles. Initial mechanistic studies reveal that a single-electron transfer radical process is potentially involved.
Authors
- Cong‐Ying Zhou (ORCID: https://orcid.org/0000-0002-2235-6070)
- Tinglan Liu
- Chengming Wang (ORCID: https://orcid.org/0000-0002-0201-1526)
- Qijing Zhang
- Lili Wu (ORCID: https://orcid.org/0000-0002-5060-852X)
Institutions
- Jinan University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1021/acs.orglett.4c02910
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- Central University Basic Research Fund of China
- Basic and Applied Basic Research Foundation of Guangdong Province