Tudor-SN exacerbates pathological vascular remodeling by promoting the polyubiquitination of PTEN via NEDD4-1
Our findings reveal that Tudor-SN deficiency significantly ameliorated pathological vascular remodeling by reducing NEDD4-1-dependent PTEN polyubiquitination, suggesting that Tudor-SN may be a novel target for preventing vascular diseases.
Authors
- Jiangcheng Shu
- Ruiqi Mao
- Minglu Liang (ORCID: https://orcid.org/0000-0002-4026-951X)
- Zhe Zheng (ORCID: https://orcid.org/0000-0003-0055-2940)
- Xiaoguang Li (ORCID: https://orcid.org/0000-0002-1726-696X)
- Yi Guo (ORCID: https://orcid.org/0000-0002-3369-5385)
- Ruijie Luo (ORCID: https://orcid.org/0000-0001-9114-0284)
- Kai Huang (ORCID: https://orcid.org/0000-0002-7121-0318)
- Yichen Wu (ORCID: https://orcid.org/0000-0002-4676-4829)
- Siyuan Fan (ORCID: https://orcid.org/0000-0003-3247-115X)
- Zilong Chen (ORCID: https://orcid.org/0009-0002-1453-3839)
- Wenjing Xu (ORCID: https://orcid.org/0000-0003-3399-0867)
- Cheng Wang (ORCID: https://orcid.org/0009-0000-6432-9794)
- Jie An
Institutions
- Hubei University of Chinese Medicine (CN)
- Hubei Provincial Center for Disease Control and Prevention (CN)
- Wuhan Union Hospital (CN)
- Hubei University of Education (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1186/s12929-024-01076-9
- Citations
- 2
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- National Natural Science Foundation of China