Licoricesaponin G2 ameliorates bleomycin-induced pulmonary fibrosis via targeting TNF-α signaling pathway and inhibiting the epithelial-mesenchymal transition
LG2 mitigates PF by suppressing TNF-α signaling pathway activation, modulating EMT, and remodeling the ECM. These results provide compelling evidence supporting the use of LG2 as a potential natural therapeutic agent for PF in clinical trials.
Authors
- Xiaolin Tong (ORCID: https://orcid.org/0000-0002-9873-4154)
- Linhua Zhao (ORCID: https://orcid.org/0000-0002-0362-7365)
- Jun Sun (ORCID: https://orcid.org/0000-0002-3664-1323)
- Xiangyan Li (ORCID: https://orcid.org/0000-0001-6780-6314)
- Daqing Zhao (ORCID: https://orcid.org/0000-0001-5678-7410)
- Yingying Yang (ORCID: https://orcid.org/0000-0002-0120-7973)
- Hang Su (ORCID: https://orcid.org/0000-0002-6877-6783)
- Zeyu Wang (ORCID: https://orcid.org/0000-0002-6675-5399)
- Xueyan Li (ORCID: https://orcid.org/0000-0001-8243-5777)
- Wei Zhang (ORCID: https://orcid.org/0000-0003-3605-9373)
- Jing Ma (ORCID: https://orcid.org/0000-0002-7144-9273)
- Lu Ding
- Zepeng Zhang (ORCID: https://orcid.org/0000-0001-7057-1341)
- Min Li (ORCID: https://orcid.org/0000-0003-2456-8795)
- Xiaoyu Zang
- Ruonan Wei
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Gansu University of Traditional Chinese Medicine (CN)
- Changchun University of Chinese Medicine (CN)
- People's Hospital of Shiyan (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-05
- DOI
- https://doi.org/10.3389/fphar.2024.1437231
- Citations
- 6
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 2.51
Funders
- People's Government of Jilin Province
- National Major Science and Technology Projects of China