Knocking down RAD51AP1 enhances chemosensitivity by inhibiting the self-renewal of CD133 positive ovarian cancer stem-like cells
The findings of this study showed that RAD51AP1 was highly expressed in OC tissue and CD133<sup>+</sup>OVCAR4 cells, and regulated the self-renewal and chemosensitivity of tumor cells through the TGF-β1/SMAD4 signaling pathway.
Authors
- Qing Ren (ORCID: https://orcid.org/0000-0002-8802-4810)
- Zhen Chen (ORCID: https://orcid.org/0000-0002-4502-0801)
- Zhiqiang Yan (ORCID: https://orcid.org/0000-0002-6432-0199)
- Lihui Lin (ORCID: https://orcid.org/0009-0003-6041-9452)
- Si-Heng Zeng
Institutions
- Fudan University (CN)
- Shanghai Ninth People's Hospital (CN)
- Zhongshan Hospital (CN)
- Hainan 301 Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1007/s12672-024-01258-9
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.23