Lynch Syndrome and Somatic Mismatch Repair Variants in Pancreas Cancer
The results of this cross-sectional study suggest that MSI-H occurs due to LS or somatic oncogenesis in PC. Orthogonal MS testing is key in PC; the artificial intelligence classifier reclassified approximately 20% of cases, most of which were low cellularity. ICB for patients with LS or somatic MSI-H PC provided significant benefit.
Authors
- Debyani Chakravarty (ORCID: https://orcid.org/0000-0001-8629-5732)
- Deborah Thurtle-Schmidt (ORCID: https://orcid.org/0000-0002-9747-9585)
- Sarah P. Suehnholz
- Kenneth H. Yu (ORCID: https://orcid.org/0000-0002-4774-2672)
- Henry S. Walch (ORCID: https://orcid.org/0000-0003-1188-350X)
- Anna M. Varghese (ORCID: https://orcid.org/0000-0001-5426-0885)
- Wungki Park (ORCID: https://orcid.org/0000-0002-8006-3102)
- Andrea Gazzo (ORCID: https://orcid.org/0009-0009-9282-4667)
- Sarah Kane (ORCID: https://orcid.org/0000-0003-1936-7067)
- Emily Harrold (ORCID: https://orcid.org/0000-0003-1733-7593)
- Catherine O’Connor (ORCID: https://orcid.org/0000-0003-4080-9149)
- Fergus Keane (ORCID: https://orcid.org/0000-0001-6651-2090)
- Megha Ranganathan (ORCID: https://orcid.org/0000-0002-3245-8812)
- David P. Kelsen (ORCID: https://orcid.org/0000-0001-6139-438X)
- Zsofia Kinga Stadler (ORCID: https://orcid.org/0000-0002-6985-2864)
- Fiyinfolu Balogun (ORCID: https://orcid.org/0000-0003-4703-1560)
- Eileen Mary O'Reilly (ORCID: https://orcid.org/0000-0002-8076-9199)
- Joshua D. Schoenfeld (ORCID: https://orcid.org/0000-0002-3970-9784)
- Alicia J. Latham (ORCID: https://orcid.org/0000-0002-9758-713X)
- Drew Moss
- Yun-Te Lin (ORCID: https://orcid.org/0000-0003-0231-7442)
- Britta Weigelt
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Davidson College (US)
- Cornell University (US)
- Mater Misericordiae University Hospital (IE)
- Kettering University (US)
- Molecular Oncology (United States) (US)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1001/jamaoncol.2024.3651
- Citations
- 16
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 6.80