Nickel-Catalyzed Narasaka–Heck Cyclization Carbonylation of Unsaturated Oxime Esters with Arylboronic Acids
The Narasaka–Heck reaction is one of the most straightforward methods for constructing pyrroline derivatives. Herein, we report a novel nickel-catalyzed three-component carbonylation reaction, which cleverly realizes the continuous construction of C(sp3)–N bonds and C(sp3)–C(sp2) bonds and effectively promotes the synthesis of acyl-substituted pyrroline derivatives. Furthermore, this strategy not only expands the conversion pathway of γ,δ-unsaturated oxime esters but also provides a new method for the synthesis of nitrogen-containing heterocyclic compounds.
Authors
- Dongping Chen (ORCID: https://orcid.org/0009-0009-9848-2557)
- Dong‐Yu Miao
- Xi‐Cun Wang (ORCID: https://orcid.org/0000-0003-3770-9817)
- Shun‐Xi Li
- Yi‐Feng Qiu (ORCID: https://orcid.org/0000-0002-2747-9598)
- Fan Gao
- Ming Li (ORCID: https://orcid.org/0000-0002-2207-0873)
- Zheng‐Jun Quan (ORCID: https://orcid.org/0000-0002-4393-3594)
- Shan-Mei Xu
- Yong‐Min Liang (ORCID: https://orcid.org/0000-0001-8280-8211)
Institutions
- Northwest Normal University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1021/acs.orglett.4c02647
- Citations
- 15
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- Northwest Normal University
- National Natural Science Foundation of China