<i>Escherichia coli</i> ST117: exploring the zoonotic hypothesis
Certain extraintestinal pathogenic <i>Escherichia coli</i> (ExPEC) are particularly important as they affect humans and animals. Lineages, such as ST117, are predominant in poultry and frequent carriers of antibiotic resistance, presenting a risk to humans handling or ingesting poultry products. We analyzed ExPEC isolates causing outbreaks in Brazilian poultry, focusing on the ST117 as the most detected lineage. Genomic comparisons with international isolates from humans and animals were performed describing the potential zoonotic profile. The Brazilian ST117 isolates carried resistance determinants against critical antibiotics, mainly on plasmids, in some cases identical to those carried by international isolates. South American ST117 isolates from all sources generally exhibit more resistance, including to critical antibiotics, and worldwide, the vast majority of human isolates belonging to this lineage have a predicted poultry origin. As the world's largest poultry exporter, Brazil has an important role in developing strategies to prevent the dissemination of multidrug-resistant zoonotic ExPEC strains.
Authors
- Søren Hallstrøm (ORCID: https://orcid.org/0000-0003-2234-8860)
- André Becker Simões Saidenberg (ORCID: https://orcid.org/0000-0002-2672-0749)
- Arnoud H. M. van Vliet (ORCID: https://orcid.org/0000-0003-0203-1305)
- Marc Stegger (ORCID: https://orcid.org/0000-0003-0321-1180)
- Lance Bradley Price (ORCID: https://orcid.org/0000-0002-8746-5307)
- Sofie Marie Edslev (ORCID: https://orcid.org/0000-0002-8379-0145)
- Terezinha Knöbl (ORCID: https://orcid.org/0000-0001-7107-5710)
- Ana Angelita Sampaio Baptista (ORCID: https://orcid.org/0000-0003-0699-7246)
- Victória Galdino Pavlenco Rocha (ORCID: https://orcid.org/0000-0001-6142-6740)
- Anders Dalsgaard (ORCID: https://orcid.org/0000-0003-1765-8055)
- Daniel E. Park (ORCID: https://orcid.org/0000-0001-5139-5397)
- Francisca Maria Sousa Barbosa (ORCID: https://orcid.org/0000-0002-9058-9298)
- Maliha Aziz (ORCID: https://orcid.org/0000-0002-8347-5487)
- B. dos Santos Queiroz
- A. G. Rasmussen
Institutions
- Statens Serum Institut (DK)
- University of Copenhagen (DK)
- Universidade Estadual de Londrina (BR)
- Milken Institute (US)
- Murdoch University (AU)
- George Washington University (US)
- University of Surrey (GB)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1128/spectrum.00466-24
- Citations
- 16
- Primary Topic
- Escherichia coli research studies
- Type
- article
- Field-Weighted Citation Impact
- 9.88
Funders
- Wellcome Trust
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico