Identifying crucial lncRNAs and mRNAs in hypoxia-induced A549 lung cancer cells and investigating their underlying mechanisms via high-throughput sequencing
Our findings suggest a potential involvement of SNAP25-AS1, RP11-58O9.2, TENM4, XRCC2, LINC01164, VLDLR-AS1, RP11-14I17.2, and CDKN1A in the development of hypoxia-induced lung cancer. These key lncRNAs and mRNAs exert their functions through diverse mechanisms, including the competitive endogenous RNA (ceRNA) pathway.
Authors
- Lili Deng (ORCID: https://orcid.org/0009-0009-5472-0437)
- Yongxia Bao (ORCID: https://orcid.org/0009-0003-1743-9589)
- Lin Lin (ORCID: https://orcid.org/0000-0002-4904-3154)
Institutions
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1371/journal.pone.0307954
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- Natural Science Foundation of Heilongjiang Province