Young small extracellular vesicles rejuvenate replicative senescence by remodeling Drp1 translocation-mediated mitochondrial dynamics
Our findings show that Dynamin-related protein 1-mediated mitochondrial disruption is associated with the replication history of bone marrow-derived mesenchymal stem cells. Young small extracellular vesicles from human exfoliated deciduous teeth stem cells alleviate replicative senescence by promoting Dynamin-related protein 1 translocation onto the mitochondria, providing evidence for a potential rejuvenation strategy.
Authors
- Wei Teng (ORCID: https://orcid.org/0000-0001-5663-1440)
- Shuqing Yang (ORCID: https://orcid.org/0000-0001-8388-0725)
- Yunyi Xie (ORCID: https://orcid.org/0000-0001-9975-8855)
- Yingying Peng (ORCID: https://orcid.org/0000-0001-5203-5211)
- Tingting Zhao (ORCID: https://orcid.org/0000-0002-7122-3362)
- Shuxuan Rong
- Yan Wang (ORCID: https://orcid.org/0009-0002-2584-9337)
Institutions
- Stomatology Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1186/s12951-024-02818-5
- Citations
- 9
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University