Unravelling the role of dipeptidyl peptidases-8/9 (DPP-8/9) in inflammatory osteoporosis: a comprehensive study investigating chrysin as a potential anti-osteoporotic agent
This study highlights the role of DPP-8/9 in inflammation-induced osteoporosis. Following inhibition of DPP-8/9, we observed improved bone markers with preservation of trabecular bone mineral density in rats. Additionally, chrysin demonstrated potential as an anti-DPP-8/9 agent, suggesting its viability for future therapeutic interventions in DPP-8/9-related inflammatory diseases.
Authors
- Mohammad Mumtaz Alam (ORCID: https://orcid.org/0000-0001-6420-8757)
- Mohammad Ahmed Khan (ORCID: https://orcid.org/0000-0002-7401-3299)
- Sayeed Ahmad (ORCID: https://orcid.org/0000-0003-1573-152X)
- Faraha Ahmed (ORCID: https://orcid.org/0000-0001-5438-0350)
- Syed Sufian Ahmad (ORCID: https://orcid.org/0000-0003-1800-2488)
Institutions
- Jamia Hamdard (IN)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2024-09-04
- DOI
- https://doi.org/10.1093/jpp/rgae109
- Citations
- 2
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Department of Science and Technology, Ministry of Science and Technology, India