Zuranolone therapy protects frontal cortex neurodevelopment and improves behavioral outcomes after preterm birth
This is the first study to assess zuranolone treatment as a neuroprotective therapy following preterm birth. Zuranolone treatment improved behavioral outcomes and structural changes in the preterm offspring, which continued long term until at least a late childhood timepoint. Clinical studies are warranted for further exploring the neuroprotective possibilities of this treatment following preterm birth.
Authors
- Julia C. Shaw (ORCID: https://orcid.org/0000-0002-3268-4609)
- Roisin A. Moloney (ORCID: https://orcid.org/0000-0003-1373-6781)
- Jonathan J. Hirst (ORCID: https://orcid.org/0000-0002-9362-5303)
- Hannah K. Palliser (ORCID: https://orcid.org/0000-0001-5783-9737)
- Carlton L. Pavy
Institutions
- Hunter Medical Research Institute (AU)
- University of Newcastle Australia (AU)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/brb3.70009
- Citations
- 3
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 3.33
Funders
- National Health and Medical Research Council